Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective-Reference-Cited by-同舟云学术

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Published:2019 Issue:19 Volume:19 Page:3152-3161
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ainslie Garrett R.¹²³⁴^ORCID,Davis Myrtle⁵⁶⁷⁴,Ewart Lorna⁸⁹¹⁰¹¹¹²,Lieberman Linda A.¹³¹⁴¹¹⁴,Rowlands David J.¹⁵¹⁶¹¹⁴,Thorley Andrew J.¹⁵¹⁶¹¹⁴^ORCID,Yoder Gorm¹⁷¹⁸¹⁹⁴,Ryan Anne M.²⁰²¹²²²³⁴

Affiliation:

1. Drug Metabolism and Pharmacokinetics

2. Theravance Biopharma US, Inc

3. South San Francisco

4. USA

5. Discovery Toxicology

6. Bristol-Myers Squibb Company

7. Princeton

8. Clinical Pharmacology and Safety Sciences

9. Biopharmaceuticals

10. AstraZeneca

11. Cambridge

12. UK

13. Exploratory Science Center

14. Merck & Co., Inc.

15. Respiratory Disease Area

16. Novartis Institutes for Biomedical Research

17. Small Molecule Pharmaceutical Development

18. Janssen Research and Development

19. Malvern

20. Global Investigative Toxicology

21. Drug Safety Research and Development

22. Pfizer Inc

23. Groton

Abstract

Drug developers seek specific advancements in the development and qualification of microphysiological lung models for the evaluation of drug safety; here these essential elements are discussed from the perspective of the biopharmaceutical industry.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C9LC00492K

Reference37 articles.

1. Impact of a five-dimensional framework on R&D productivity at AstraZeneca

2. Model-Based Drug Development: The Road to Quantitative Pharmacology

3. Microfluidic organs-on-chips

4. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

5. Reconstituting Organ-Level Lung Functions on a Chip

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