Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems-Reference-Cited by-同舟云学术

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Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

Published:2024 Issue:13 Volume:24 Page:3199-3225
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ugodnikov Alisa¹²^ORCID,Persson Henrik¹,Simmons Craig A.¹²³^ORCID

Affiliation:

1. Translational Biology & Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON M5G 1M1, Canada

2. Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada

3. Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada

Abstract

Biological barriers play key roles in homeostasis, disease physiology and drug delivery, highlighting a need for representative in vitro tools. We discuss advances and challenges in modeling and measuring barrier integrity in organ-on-chip systems.

Funder

Vetenskapsrådet

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC01027A

Reference292 articles.

1. Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor

2. Engineering and monitoring cellular barrier models

3. Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

4. In situ biosensing technologies for an organ-on-a-chip

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