An engineered ubiquitin binding coiled coil peptide-Reference-Cited by-同舟云学术

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An engineered ubiquitin binding coiled coil peptide

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Vosbein Pernille¹^ORCID,Vergara Paula Paredes²,Huang Danny T.²³,Thomson Andrew R.¹^ORCID

Affiliation:

1. School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK

2. Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK

3. School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK

Abstract

Mapping of key binding residues onto a designed coiled-coil peptide scaffold results in an enhanced-affinity binder of the protein Ubiquitin.

Funder

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04204B

Reference33 articles.

1. A structural perspective on protein–protein interactions

2. Peptide-based inhibitors of protein–protein interactions

3. Predicting Protein–Protein Interactions from the Molecular to the Proteome Level

4. The characterization of protein interactions – what, how and how much?

5. Peptidomimetics: A Synthetic Tool for Inhibiting Protein–Protein Interactions in Cancer

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