Fluorine effects in organocatalysis – asymmetric Brønsted acid assisted Lewis base catalysis for the synthesis of trifluoromethylated heterocycles exploiting the negative hyperconjugation of the CF3-group-Reference-Cited by-同舟云学术

Fluorine effects in organocatalysis – asymmetric Brønsted acid assisted Lewis base catalysis for the synthesis of trifluoromethylated heterocycles exploiting the negative hyperconjugation of the CF3-group

Published:2014 Issue:58 Volume:50 Page:7889-7892
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Volla Chandra M. R.¹²³,Das Arindam¹²³,Atodiresei Iuliana¹²³,Rueping Magnus¹²³

Affiliation:

1. RWTH Aachen University

2. Institute of Organic Chemistry

3. D-52074 Aachen, Germany

Abstract

An efficient Brønsted acid assisted Lewis base catalysis protocol for the synthesis of enantiomerically pure trifluoromethylated dihydropyridazines has been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC03229B

Reference57 articles.

1. Introduction: Fluorine Chemistry

2. R. Filler , Y.Kobayashi and L. M.Yagupolskii , Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications , Elsevier , Amsterdam , 1993

3. Catalysis for fluorination and trifluoromethylation

4. Fluorine in Pharmaceuticals: Looking Beyond Intuition

5. Fluorine in medicinal chemistry

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks;Beilstein Journal of Organic Chemistry;2023-11-15

2. The cyclization/rearrangement of α-hydroxy ketones with trifluoromethyl N-acylhydrazones to synthesize multi-substituted trifluoromethyloxazolines;Chemical Communications;2023

3. Recent Developments in Enantioselective Organocatalytic Cascade Reactions for the Construction of Halogenated Ring Systems;European Journal of Organic Chemistry;2021-06-28

4. Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs;Chemical Science;2021

5. α-Keto hydrazones in asymmetric aminocatalysis: reactivity through β-amino aza-dienamine intermediates;Organic Chemistry Frontiers;2021