Pre-formulation of an additive combination of two antimicrobial agents, clofazimine and nisin A, to boost antimicrobial activity

Author:

Naranjo Mateo Flores1ORCID,Kumar Ajay1,Ratrey Poonam1,Hudson Sarah P.1ORCID

Affiliation:

1. Department of Chemical Sciences, SSPC, Science Foundation Ireland Research Centre for Pharmaceuticals, Bernal Institute, University of Limerick, Castletroy, Limerick, V94 T9PX, Ireland

Abstract

A novel design platform for new antimicrobial peptide therapies using a blend of pre-formulation technologies with the multi-hurdle approach of selecting combinations of antimicrobial drugs with different effects on microbes.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference43 articles.

1. World Health Organization , Antimicrobial Resistance Fact Sheet, 2020

2. Understanding and overcoming antibiotic resistance

3. World Health Organization , Lack of new antibiotics threatens global efforts to contain drug-resistant infections, Geneva, 2020

4. Drugs for bad bugs: confronting the challenges of antibacterial discovery

5. Understanding the mechanisms and drivers of antimicrobial resistance

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