Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates-Reference-Cited by-同舟云学术

Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates

Published:2021 Issue:32 Volume:57 Page:3877-3880
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yamamoto Yoshihiko¹²³⁴⁵^ORCID,Takase Tomoya¹²³⁴⁵,Kuroyanagi Eisuke¹²³⁴⁵,Yasui Takeshi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Basic Medicinal Sciences

2. Graduate School of Pharmaceutical Sciences

3. Nagoya University

4. Chikusa

5. Japan

Abstract

The Fe(OTf)₃-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes.

Funder

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC00765C

Reference46 articles.

1. Chiral 1,1-diaryl compounds as important pharmacophores

2. Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

3. Fluorine in Medicinal Chemistry

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