Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950
Author:
Affiliation:
1. Institute of Medicinal Biotechnology
2. Chinese Academy of Medical Sciences
3. Peking Union Medical College
4. Beijing 100050
5. China
6. School of Chinese Materia Medica
7. Beijing University of Chinese Medicine
8. Beijing 100102
Abstract
Ahmpatinin iBu and statinin iBu, two new linear peptides, were isolated from Streptomyces sp. CPCC 202950. Ahmpatinin iBu exhibited significant inhibitory activity against HIV-1 protease with an IC50 value of 1.79 nM.
Funder
Natural Science Foundation of Beijing Municipality
National Infrastructure for Microbiological Resources
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA13241G
Reference31 articles.
1. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
2. Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?
3. Prodrugs of HIV protease inhibitors—saquinavir, indinavir and nelfinavir—derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity
4. Defeating AIDS—advancing global health
5. World Health Organization, Global Health Observatory (GHO) data, http://www.who.int/gho/hiv/en/ , accessed Dec 2, 2017
Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Non-Canonical Amino Acids in Analyses of Protease Structure and Function;International Journal of Molecular Sciences;2023-09-13
2. Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.;Frontiers in Chemistry;2023-01-12
3. Use of soil actinomycetes for pharmaceutical, food, agricultural, and environmental purposes;3 Biotech;2022-08-19
4. Actinobacteria Community and Their Antibacterial and Cytotoxic Activity on the Weizhou and Xieyang Volcanic Islands in the Beibu Gulf of China;Frontiers in Microbiology;2022-07-12
5. Impact of novel microbial secondary metabolites on the pharma industry;Applied Microbiology and Biotechnology;2022-02-21
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3