Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950-Reference-Cited by-同舟云学术

Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950

Published:2018 Issue:10 Volume:8 Page:5138-5144
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chen Ming-Hua¹²³⁴⁵^ORCID,Chang Shan-Shan¹²³⁴⁵,Dong Biao¹²³⁴⁵,Yu Li-Yan¹²³⁴⁵,Wu Ye-Xiang¹²³⁴⁵,Wang Ren-Zhong¹²³⁴⁵,Jiang Wei¹²³⁴⁵,Gao Zeng-Ping⁶⁷⁸⁵,Si Shu-Yi¹²³⁴⁵

Affiliation:

1. Institute of Medicinal Biotechnology

2. Chinese Academy of Medical Sciences

3. Peking Union Medical College

4. Beijing 100050

5. China

6. School of Chinese Materia Medica

7. Beijing University of Chinese Medicine

8. Beijing 100102

Abstract

Ahmpatinin ⁱBu and statinin ⁱBu, two new linear peptides, were isolated from Streptomyces sp. CPCC 202950. Ahmpatinin ⁱBu exhibited significant inhibitory activity against HIV-1 protease with an IC₅₀ value of 1.79 nM.

Funder

Natural Science Foundation of Beijing Municipality

National Infrastructure for Microbiological Resources

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA13241G

Reference31 articles.

1. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS