A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA-Reference-Cited by-同舟云学术

A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA

Published:2020 Issue:24 Volume:12 Page:12950-12957
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Deiana Marco¹²³⁴^ORCID,Chand Karam⁵²³⁴^ORCID,Jamroskovic Jan¹²³⁴^ORCID,Das Rabindra Nath⁵²³⁴^ORCID,Obi Ikenna¹²³⁴^ORCID,Chorell Erik⁵²³⁴^ORCID,Sabouri Nasim¹²³⁴^ORCID

Affiliation:

1. Department of Medical Biochemistry and Biophysics

2. Umeå University

3. 90187 Umeå

4. Sweden

5. Department of Chemistry

Abstract

A self-assembled light-up rotor probe with outstanding sensitivity and selectivity for the c-MYC promoter G-quadruplex DNA is reported.

Funder

Knut och Alice Wallenbergs Stiftelse

Vetenskapsrådet

Kempestiftelserna

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR03404E

Reference45 articles.

1. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

2. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

3. Quadruplex nucleic acids as targets for anticancer therapeutics

4. Translocations involving c-myc and c-myc function

5. Function of the c-Myc oncoprotein in chromatin remodeling and transcription

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