A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation-Reference-Cited by-同舟云学术

A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation

Published:2021 Issue:6 Volume:21 Page:1061-1072
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Crippa Martina¹²³⁴⁵,Bersini Simone¹²³⁴,Gilardi Mara⁶⁷⁸⁹¹⁰,Arrigoni Chiara¹²³⁴^ORCID,Gamba Sara¹¹¹²¹³⁹^ORCID,Falanga Anna¹¹¹²¹³⁹^ORCID,Candrian Christian¹²³⁴¹⁴,Dubini Gabriele⁵¹⁵¹⁶⁹,Vanoni Marco¹⁷¹⁸¹⁶⁹,Moretti Matteo¹²³⁴⁶^ORCID

Affiliation:

1. Regenerative Medicine Technologies Lab

2. Ente Ospedaliero Cantonale (EOC)

3. 6900 Lugano

4. Switzerland

5. Laboratory of Biological Structures Mechanics, Chemistry, Material and Chemical Engineering Department “Giulio Natta”

6. Cell and Tissue Engineering Laboratory

7. IRCCS Istituto Ortopedico Galeazzi

8. 20161 Milan

9. Italy

10. Institute of Pathology

11. Division of Immunohematology and Transfusion Medicine

12. Papa Giovanni XXIII Hospital

13. Bergamo

14. Facoltà di Scienze Biomediche

15. Politecnico di Milano

16. Milan

17. Dipartimento di Biotecnologie e Bioscienze

18. Università Milano Bicocca

Abstract

Our microfluidic model of early metastatic niche reproduced the extravasation of breast cancer cells in presence of immune blood cells and allowed us to test the effect of an already approved inhibitor of integrin β₃ on cancer cell extravasation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D0LC01011A

Reference64 articles.

1. Metastatic colonization by circulating tumour cells

2. Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

3. The Initial Hours of Metastasis: The Importance of Cooperative Host–Tumor Cell Interactions during Hematogenous Dissemination

4. The metastatic niche: adapting the foreign soil

5. Platelets guide the formation of early metastatic niches

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