Synthesis, in vitro anti-plasmodial potency, in-silico-cum-SPR binding with inhibition of PfPyridoxal synthase and rapid parasiticidal action by 3,5-bis{(E) arylidene}-N-methyl-4-piperidones-Reference-Cited by-同舟云学术

Synthesis, in vitro anti-plasmodial potency, in-silico-cum-SPR binding with inhibition of PfPyridoxal synthase and rapid parasiticidal action by 3,5-bis{(E) arylidene}-N-methyl-4-piperidones

Published:2021 Issue:47 Volume:45 Page:22150-22165
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Rokkam Siva Kumar¹^ORCID,Yadav Mamta²^ORCID,Joshi Mayank³^ORCID,Choudhury Angshuman Roy³^ORCID,Sahal Dinkar²^ORCID,Golakoti Nageswara Rao¹^ORCID

Affiliation:

1. Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Andhra Pradesh, India

2. Malaria Drug Discovery Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

3. Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Sector 81, S. A. S. Nagar, Manauli PO, Mohali, Punjab, 140306, India

Abstract

DANMPs have been identified as new pharmacophores that have the ability to target PfPyridoxal synthase and cause rapid killing of the malaria parasite.

Funder

Department of Science and Technology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ04604G

Reference64 articles.

1. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

2. Malaria: Biology and Disease

3. Cytokines and Chemokines in Cerebral Malaria Pathogenesis

4. WHO , 2016 world malaria report , World Health Organization , Switzerland , 2016

5. Malaria biology and disease pathogenesis: insights for new treatments

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