Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study-Reference-Cited by-同舟云学术

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Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study

Published:2019 Issue:11 Volume:11 Page:1800-1804
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Carlotto Silvia¹²³⁴⁵^ORCID,Bonna Arkadiusz⁶⁷⁸⁹¹⁰^ORCID,Bossak-Ahmad Karolina¹¹¹²¹³¹⁴,Bal Wojciech¹¹¹²¹³¹⁴^ORCID,Porchia Marina¹⁵¹⁶¹⁷⁵^ORCID,Casarin Maurizio¹²³⁴⁵^ORCID,Tisato Francesco¹⁵¹⁶¹⁷⁵^ORCID

Affiliation:

1. Dipartimento di Scienze Chimiche

2. Università degli Studi di Padova

3. Via Marzolo 1

4. 35131 Padova

5. Italy

6. Department of Biochemistry

7. University of Cambridge

8. Tennis Court Road

9. Cambridge

10. UK

11. Institute of Biochemistry and Biophysics

12. Polish Academy of Sciences, Pawińskiego 5a

13. 02-106 Warsaw

14. Poland

15. ICMATE-CNR

16. Corso Stati Uniti 4

17. 35127 Padova

Abstract

Model peptides relevant to hCtr1 transchelate Cu^I from the anti-tumour [Cu^I(PTA)₄]⁺ complex before metal internalization into tumor cells.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MT/C9MT00236G

Reference32 articles.

1. Biochemical Characterization of the Human Copper Transporter Ctr1

2. Copper entry into human cells: progress and unanswered questions

3. How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal

4. Cisplatin Stabilizes a Multimeric Complex of the Human Ctr1 Copper Transporter

5. Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I)

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