‘Click cyclic ADP-ribose’: a neutral second messenger mimic-Reference-Cited by-同舟云学术

‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Published:2014 Issue:19 Volume:50 Page:2458-2461
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Swarbrick Joanna M.¹²³⁴,Graeff Richard⁵⁶⁷,Garnham Clive⁸⁹¹⁰,Thomas Mark P.¹²³⁴,Galione Antony⁸⁹¹⁰,Potter Barry V. L.⁵⁶⁷

Affiliation:

1. Wolfson Laboratory of Medicinal Chemistry

2. Dept. of Pharmacy and Pharmacology

3. University of Bath

4. Bath, UK

5. Department of Physiology

6. University of Hong Kong

7. Hong Kong, China

8. Department of Pharmacology

9. University of Oxford

10. Oxford OX1 3QT, UK

Abstract

Neutral synthetic analogues of the second messenger cADPR with a 1,2,3-triazole pyrophosphate bioisostere retain the ability to activate Ca²⁺release and to inhibit hydrolysis of cADPR by CD38.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C3CC49249D

Reference42 articles.

1. Regulation of Calcium Signaling by the Second Messenger Cyclic Adenosine Diphosphoribose (cADPR)

2. The versatility and universality of calcium signalling

3. Inositol trisphosphate and calcium signalling

4. Identification of a chemical probe for NAADP by virtual screening

5. Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds

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