Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)-Reference-Cited by-同舟云学术

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

Published:2020 Issue:3 Volume:10 Page:1776-1785
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Baszczyňski Ondřej¹²³⁴⁵,Watt Joanna M.⁶⁷⁸⁹⁵^ORCID,Rozewitz Monika D.¹⁰¹¹¹²¹³¹⁴,Fliegert Ralf¹⁰¹¹¹²¹³¹⁴,Guse Andreas H.¹⁰¹¹¹²¹³¹⁴,Potter Barry V. L.⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Wolfson Laboratory of Medicinal Chemistry

2. Department of Pharmacy and Pharmacology

3. University of Bath

4. Bath

5. UK

6. Medicinal Chemistry and Drug Discovery

7. Department of Pharmacology

8. University of Oxford

9. Oxford

10. The Calcium Signalling Group

11. Department of Biochemistry and Molecular Cell Biology

12. University Medical Center Hamburg-Eppendorf

13. 20246 Hamburg

14. Germany

Abstract

Pyrophosphate replacement using phosphonoacetate isosteres – tools to study biological targets of ADPR.

Funder

Wellcome Trust

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA09284F

Reference32 articles.

1. Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction

2. The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

3. PARP inhibitors: Synthetic lethality in the clinic

4. Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

5. ‘Click cyclic ADP-ribose’: a neutral second messenger mimic

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