The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT6 receptor antagonists and beyond-Reference-Cited by-同舟云学术

The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT6 receptor antagonists and beyond

Published:2018 Issue:33 Volume:8 Page:18672-18681
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kalinowska-Tłuścik Justyna¹²³⁴⁵^ORCID,Staroń Jakub⁶⁷⁸⁵,Krawczuk Anna¹²³⁴⁵,Mordalski Stefan⁶⁷⁸⁵,Warszycki Dawid⁶⁷⁸⁵,Satała Grzegorz⁶⁷⁸⁵,Hogendorf Adam S.¹²³⁴⁵,Bojarski Andrzej J.⁶⁷⁸⁵

Affiliation:

1. Department of Crystal Chemistry and Crystal Physic

2. Faculty of Chemistry

3. Jagiellonian University

4. 30-387 Kraków

5. Poland

6. Department of Medicinal Chemistry

7. Institute of Pharmacology Polish Academy of Sciences

8. 31-343 Kraków

Abstract

The impact of weak intramolecular C–H⋯O interactions on the conformational stability of bis-arylsulfones is discussed, suggesting different role of sulfonyl group in the ligand – 5HT₆ receptor interaction.

Funder

Narodowe Centrum Nauki

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA03107J

Reference63 articles.

1. Intramolecular Hydrogen Bonding in Medicinal Chemistry

2. What Can We Learn from Molecular Recognition in Protein–Ligand Complexes for the Design of New Drugs?