An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes

Author:

Mészáros János P.12345ORCID,Poljarević Jelena M.12345ORCID,Szatmári István6345,Csuvik Oszkár6345,Fülöp Ferenc6345,Szoboszlai Norbert789105,Spengler Gabriella1134512,Enyedy Éva A.12345ORCID

Affiliation:

1. Department of Inorganic and Analytical Chemistry

2. Interdisciplinary Excellence Centre

3. University of Szeged

4. H-6720 Szeged

5. Hungary

6. Institute of Pharmaceutical Chemistry and Stereochemistry Research Group of Hungarian Academy of Sciences

7. Laboratory for Environmental Chemistry and Bioanalytics

8. Institute of Chemistry

9. Eötvös Lóránd University

10. H-1117 Budapest

11. MTA-SZTE Lendület Functional Metal Complexes Research Group

12. Department of Medical Microbiology and Immunobiology

Abstract

Synthesis and characterization of an 8-hydroxyquinoline–proline hybrid, and its complex formation with half-sandwich organometallic cations: aqueous chemistry, lipophilicity, cellular uptake and anticancer activity.

Funder

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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