An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes-Reference-Cited by-同舟云学术

An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes

Published:2020 Issue:23 Volume:49 Page:7977-7992
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Mészáros János P.¹²³⁴⁵^ORCID,Poljarević Jelena M.¹²³⁴⁵^ORCID,Szatmári István⁶³⁴⁵,Csuvik Oszkár⁶³⁴⁵,Fülöp Ferenc⁶³⁴⁵,Szoboszlai Norbert⁷⁸⁹¹⁰⁵,Spengler Gabriella¹¹³⁴⁵¹²,Enyedy Éva A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Inorganic and Analytical Chemistry

2. Interdisciplinary Excellence Centre

3. University of Szeged

4. H-6720 Szeged

5. Hungary

6. Institute of Pharmaceutical Chemistry and Stereochemistry Research Group of Hungarian Academy of Sciences

7. Laboratory for Environmental Chemistry and Bioanalytics

8. Institute of Chemistry

9. Eötvös Lóránd University

10. H-1117 Budapest

11. MTA-SZTE Lendület Functional Metal Complexes Research Group

12. Department of Medical Microbiology and Immunobiology

Abstract

Synthesis and characterization of an 8-hydroxyquinoline–proline hybrid, and its complex formation with half-sandwich organometallic cations: aqueous chemistry, lipophilicity, cellular uptake and anticancer activity.

Funder

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01256D

Reference46 articles.

1. Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

2. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced Toxicity

3. 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential