Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activity-Reference-Cited by-同舟云学术

Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activity

Published:2022 Issue:37 Volume:12 Page:24192-24207
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Nivetha Narayanasamy¹,Martiz Reshma Mary²,Patil Shashank M.²,Ramu Ramith²,Sreenivasa Swamy³,Velmathi Sivan¹^ORCID

Affiliation:

1. Organic and Polymer Synthesis Laboratory, Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620 015, Tamil Nadu, India

2. Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, 570 015, Karnataka, India

3. Department of Chemistry, University College of Science, Tumkur University, Tumkur, 572 103, Karnataka, India

Abstract

A highly stereoselective, three-component method has been developed for the synthesis of pyrrolidine and pyrrolizidine containing spirooxindole derivatives that exhibits excellent anti-diabetic activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04452H

Reference58 articles.

1. Strategies for Innovation in Multicomponent Reaction Design

2. Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

3. Spirooxindoles: Promising scaffolds for anticancer agents

4. Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents

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