Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents-Reference-Cited by-同舟云学术

Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents

Published:2020 Issue:21 Volume:10 Page:12262-12271
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Teja Chitrala¹²³⁴⁵,Babu Spoorthy N.⁶⁴⁵⁷,Noor Ayesha⁶⁴⁵⁷,Daniel J. Arul⁸⁹⁴⁵⁷,Devi S. Asha⁸⁹⁴⁵⁷,Nawaz Khan Fazlur Rahman¹²³⁴⁵^ORCID

Affiliation:

1. Organic and Medicinal Chemistry Research Laboratory

2. Department of Chemistry

3. School of Advanced Sciences

4. Vellore Institute of Technology

5. Vellore-632014

6. Centre for Bio Separation Technology

7. India

8. Department of Biomedical Sciences

9. School of Bioscience and Technology

Abstract

A series of spiro-[indoline-3,3′-pyrrolizin/pyrrolidin]-2-ones were synthesized from Cu–TEMPO catalyzed dehydrogenation followed by 1,3-dipolar cycloaddition of azomethine ylides via decarboxylative condensation, resulting in high regioselectivities and yields.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01553A

Reference77 articles.

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2. Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

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4. Spirooxindoles: Promising scaffolds for anticancer agents

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