Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives-Reference-Cited by-同舟云学术

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives

Published:2018 Issue:29 Volume:16 Page:5254-5274
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Longin Ondřej¹²³⁴⁵,Hezwani Mohammed¹²³⁴⁵,van de Langemheen Helmus¹²³⁴⁵,Liskamp Rob M. J.¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry

2. Joseph Black Building

3. University of Glasgow

4. University Avenue

5. Glasgow G12 8QQ

Abstract

Downsizing of antibodies: molecular construction of chemo-synthetic antibodies of infliximab by scaffolding of three CDR loops yields synthetic antibodies binding hTNFα.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01104D

Reference23 articles.

1. A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold

2. Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries

3. Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold

4. An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics

5. Insoluble drug delivery strategies: review of recent advances and business prospects

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