Introducing a sulfone-embedded anhydride to the anhydride-imine reaction for the modular synthesis of N-heterocyclic sulfones bearing vicinal stereocenters-Reference-Cited by-同舟云学术

Introducing a sulfone-embedded anhydride to the anhydride-imine reaction for the modular synthesis of N-heterocyclic sulfones bearing vicinal stereocenters

Published:2023 Issue:21 Volume:13 Page:14355-14360
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Beng Timothy K.¹^ORCID,Garcia Jorge¹,Eichwald Jane¹,Borg Claire¹

Affiliation:

1. Department of Chemistry, Central Washington University, Ellensburg, WA 98926, USA

Abstract

A flexible approach to sp3-rich N-heterocyclic sulfones, which hinges on the efficient annulation of an easy-to-prepare sulfone-embedded anhydride with 1,3-azadienes and aryl aldimines, is described.

Funder

Central Washington University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01812A

Reference58 articles.

1. Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

4. On the origins of three-dimensionality in drug-like molecules

5. Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Revisiting the 1,3-azadiene-succinic anhydride annulation reaction for the stereocontrolled synthesis of allylic 2-oxopyrrolidines bearing up to four contiguous stereocenters;RSC Advances;2024

2. Harnessing the 1,3-azadiene-anhydride reaction for the regioselective and stereocontrolled synthesis of lactam-fused bromotetrahydropyrans by bromoetherification of lactam-tethered trisubstituted tertiary alkenols;RSC Advances;2024

3. Regiodivergent synthesis of sulfone-tethered lactam–lactones bearing four contiguous stereocenters;RSC Advances;2023