Translational PK–PD for targeted protein degradation-Reference-Cited by-同舟云学术

Translational PK–PD for targeted protein degradation

Published:2022 Issue:9 Volume:51 Page:3477-3486
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Bartlett Derek W.¹^ORCID,Gilbert Adam M.²^ORCID

Affiliation:

1. Pharmacokinetics, Dynamics, & Metabolism, Pfizer Worldwide Research, Development and Medical, Pfizer Inc, San Diego, CA, USA

2. Discovery Sciences, Pfizer Worldwide Research, Development and Medical, Pfizer Inc, Groton, CT, USA

Abstract

This tutorial review provides practical insights and a proposed roadmap for building the translational PK–PD understanding for protein degrader therapeutics.

Funder

Pfizer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00114D

Reference33 articles.

1. PROTAC targeted protein degraders: the past is prologue

2. The rise and rise of protein degradation: Opportunities and challenges ahead

3. Targeted protein degradation: A promise for undruggable proteins

4. Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

5. History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications

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