Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas-Reference-Cited by-同舟云学术

Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas

Published:2021 Issue:30 Volume:12 Page:10380-10387
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Suh Sung-Eun¹²³⁴^ORCID,Nkulu Leah E.¹²³⁴,Lin Shishi⁵⁶⁷⁴,Krska Shane W.⁵⁶⁷⁴^ORCID,Stahl Shannon S.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Wisconsin-Madison

3. Madison

4. USA

5. Chemistry Capabilities for Accelerating Therapeutics

6. Merck & Co., Inc.

7. Kenilworth

Abstract

A copper-based catalyst system composed of commercially available reagents enables C–H isocyanation with exquisite (hetero)benzylic site selectivity, enabling high-throughput access to pharmaceutically relevant ureas via coupling with amines.

Funder

National Institute of General Medical Sciences

National Science Foundation

Merck

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02049H

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