An ovarian spheroid based tumor model that represents vascularized tumors and enables the investigation of nanomedicine therapeutics

Author:

Singh Manu Smriti12345,Goldsmith Meir12345,Thakur Kavita67849,Chatterjee Sushmita12345,Landesman-Milo Dalit12345,Levy Tally12345,Kunz-Schughart Leoni A.1011121314,Barenholz Yechezkel1516171819,Peer Dan12345ORCID

Affiliation:

1. Laboratory of Precision NanoMedicine

2. Tel Aviv University

3. Tel Aviv 69978

4. Israel

5. School of Molecular Cell Biology & Biotechnology

6. Department of Pathology

7. Tel Aviv Sourasky Medical Center

8. Tel Aviv 62431

9. Sackler Faculty of Medicine

10. OncoRay – National Center for Radiation Research in Oncology

11. Faculty of Medicine and University Hospital Carl Gustav Carus

12. Technische Universitat Dresden and Helmholtz-Zentrum Dresden-Rossendorf

13. 01307 Dresden

14. Germany

15. Laboratory of Membrane and Liposome Research

16. Department of Biochemistry and Molecular Biology

17. Institute for Medical Research Israel-Canada (IMRIC)

18. The Hebrew University-Hadassah Medical School

19. Jerusalem

Abstract

3D tumors created by simple subcutaneous spheroid injection represents a robust and more vascular murine tumor model and can be a relevant platform to test anti-cancer therapy.

Funder

Israel Science Foundation

Rivkin Center for Ovarian Cancer

Tel Aviv University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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