Theoretical insights into the reductive metabolism of CCl4 by cytochrome P450 enzymes and the CCl4-dependent suicidal inactivation of P450-Reference-Cited by-同舟云学术

Theoretical insights into the reductive metabolism of CCl4 by cytochrome P450 enzymes and the CCl4-dependent suicidal inactivation of P450

Published:2014 Issue:39 Volume:43 Page:14833-14840
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Li Xiao-Xi¹²³⁴⁵,Zheng Qing-Chuan¹²³⁴,Wang Yong⁵⁶⁷,Zhang Hong-Xing¹²³⁴

Affiliation:

1. State Key Laboratory of Theoretical and Computational Chemistry

2. Institute of Theoretical Chemistry

3. Jilin University

4. Changchun 130023, People's Republic of China

5. Dalian Institute of Chemical Physics

6. Chinese Academy of Sciences

7. Dalian 116023, People's Republic of China

Abstract

The one-electron reduction product, ˙CCl₃, irreversibly inactivates P450 via covalently binding to the meso-carbon, whereas the two successive one-electron reductions product, :CCl₂, reversibly inhibits P450 by coordinating to iron.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C4DT02065K

Reference80 articles.

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