Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups-Reference-Cited by-同舟云学术

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

Published:2016 Issue:15 Volume:14 Page:3782-3786
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Burslem George M.¹²³⁴⁵,Kyle Hannah F.⁵²³⁴⁶,Prabhakaran Panchami¹²³⁴⁵,Breeze Alexander L.⁵²³⁴⁶,Edwards Thomas A.⁵²³⁴⁶,Warriner Stuart L.¹²³⁴⁵,Nelson Adam¹²³⁴⁵,Wilson Andrew J.¹²³⁴⁵

Affiliation:

1. School of Chemistry

2. University of Leeds

3. Leeds

4. UK

5. Astbury Centre for Structural Molecular Biology

6. School of Molecular and Cellular Biology

Abstract

New routes are developed to allow introduction of sensitive side-chains and synthesis of challenging proteomimetic sequences.

Funder

European Research Council

Engineering and Physical Sciences Research Council

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00078A

Reference39 articles.

1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2. Modulators of Protein–Protein Interactions

3. Inhibition of α-helix-mediated protein–protein interactions using designed molecules

4. Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein–protein interactions

5. Toward Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix

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