Electrochemical enantioselective dihydroxylation reaction of <i>N</i>-alkenyl nucleobases for the construction of chiral acyclic nucleosides-Reference-Cited by-同舟云学术

Electrochemical enantioselective dihydroxylation reaction of N-alkenyl nucleobases for the construction of chiral acyclic nucleosides

Published:2022 Issue:18 Volume:9 Page:4818-4822
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Qi-Ying¹,Lu Pei-Xian¹,Wang Song-Lin²,Li Lu-Xin¹,Qu Gui-Rong¹,Guo Hai-Ming¹^ORCID

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China

2. School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China

Abstract

A simple and sustainable KI-mediated electrochemical enantioselective dihydroxylation reaction for the synthesis of chiral acyclic nucleosides was developed for the first time with only a 0.1 mol% Os catalyst.

Funder

Henan Provincial Science and Technology Research Project

Henan Key Laboratory of Organic Functional Molecules and Drug Innovation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00971D

Reference38 articles.

1. Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer