Design, physico-chemical characterization and in vitro biological activity of organogold(iii) glycoconjugates-Reference-Cited by-同舟云学术

Design, physico-chemical characterization and in vitro biological activity of organogold(iii) glycoconjugates

Published:2021 Issue:25 Volume:50 Page:8963-8979
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Pettenuzzo Andrea¹²³⁴⁵^ORCID,Vezzù Keti⁶⁷⁸⁹^ORCID,Di Paolo Maria Luisa⁶¹⁰⁸⁹^ORCID,Fotopoulou Eirini¹²³⁴⁵^ORCID,Marchiò Luciano¹¹¹²¹³¹⁴⁹^ORCID,Via Lisa Dalla⁶¹⁵⁸⁹^ORCID,Ronconi Luca¹²³⁴⁵^ORCID

Affiliation:

1. National University of Ireland Galway

2. School of Chemistry

3. University Road

4. H91 TK33 Galway

5. Ireland

6. University of Padova

7. Department of Industrial Engineering

8. 35131 Padova

9. Italy

10. Department of Molecular Medicine

11. University of Parma

12. Department of Chemistry

13. Life Sciences and Environmental Sustainability

14. 43124 Parma

15. Department of Pharmaceutical and Pharmacological Sciences

Abstract

Once taken up by tumor cells via a facilitated diffusion mechanism, organogold(iii)–dithiocarbamato glycoconjugates exert antiproliferative activity by inhibiting topoisomerases I & II and inducing oxidative stress through the generation of ROS.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

National University of Ireland, Galway

Irish Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT01100F

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