Synthesis, Characterisation, and <i>in vitro</i> Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes-Reference-Cited by-同舟云学术

Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes

Published:2023-07-31 Issue:8 Volume:106 Page:
ISSN:0018-019X
Container-title:Helvetica Chimica Acta
language:en
Short-container-title:Helvetica Chimica Acta

Author:

Soldevila‐Barreda Joan J.¹^ORCID,Pettenuzzo Andrea²^ORCID,Azmanova Maria¹^ORCID,Rafols Laia¹^ORCID,Attia Amr A. A.³^ORCID,Lupan Alexandru³^ORCID,Ronconi Luca²^ORCID,Barry Nicolas P. E.¹^ORCID,Pitto‐Barry Anaïs¹⁴^ORCID

Affiliation:

1. School of Chemistry and Biosciences University of Bradford UK-BD7 1DP Bradford United Kingdom

2. School of Biological and Chemical Sciences University of Galway IE-H91 TK33 Galway Ireland

3. Facultatea de Chimie şi Inginerie Chimică Universitatea Babeş-Bolyai RO-400028 Cluj-Napoca Romania

4. Université Paris-Saclay, CNRS Institut Galien Paris-Saclay FR-91400 Orsay France

Abstract

AbstractThe synthesis by transmetallation and in‐depth characterisation by IR spectroscopy of five half‐sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.

Funder

University of Bradford

Academy of Medical Sciences

British Heart Foundation

University of Galway

Irish Research Council

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Biochemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hlca.202300064

Reference105 articles.

1. The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

2. Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications

3. A. M. Pizarro N. P. E. Barry P. J. Sadler ‘Metal–DNA Coordination Complexes’ in ‘Comprehensive Inorganic Chemistry II’ Vol. 3 Ed. J. Reedijk Elsevier 2013 751–784.

4. [Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

5. The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways