Target discovery of ebselen with a biotinylated probe-Reference-Cited by-同舟云学术

Target discovery of ebselen with a biotinylated probe

Published:2018 Issue:68 Volume:54 Page:9506-9509
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Chen Zhenzhen¹²³⁴⁵,Jiang Zhongyao¹²³⁴⁵,Chen Nan⁶⁷⁸⁹¹⁰,Shi Qian¹²³⁴⁵,Tong Lili¹²³⁴⁵,Kong Fanpeng¹²³⁴⁵,Cheng Xiufen¹²³⁴⁵,Chen Hao¹¹¹²¹³¹⁴^ORCID,Wang Chu⁶⁷⁸⁹¹⁰^ORCID,Tang Bo¹²³⁴⁵^ORCID

Affiliation:

1. College of Chemistry

2. Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes

3. Ministry of Education

4. Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong

5. Institute of Molecular and Nano Science

6. Beijing National Laboratory for Molecular Sciences

7. Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education

8. College of Chemistry and Molecular Engineering, Peking University

9. Beijing

10. China

11. Department of Chemistry and Biochemistry

12. Ohio University

13. Athens

14. USA

Abstract

An activity-based protein profiling (ABPP) method for ebselen-binding proteins based on biotin-ebselen allowed for the robust identification of 462 targeted proteins, implicating multifunctional regulation of ebselen.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC04258F

Reference28 articles.

1. A novel biologically active seleno-organic compound—1

2. A Novel Biologically Active Selenoorganic Compound. VIII. Biotransformation of Ebselen

3. Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

4. Neuroprotective Effects of Ebselen on Experimental Spinal Cord Injury in Rats

5. Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

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