Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11033-014-3417-x.pdf
Reference178 articles.
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2. Ullrich V, Weber P, Meisch F, von Appen F (1996) Ebselen-binding equilibria between plasma and target proteins. Biochem Pharmacol 52(1):15–19
3. Zhao R, Masayasu H, Holmgren A (2002) Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci USA 99(13):8579–8584. doi: 10.1073/pnas.122061399
4. Antony S, Bayse CA (2011) Modeling the mechanism of the glutathione peroxidase mimic ebselen. Inorg Chem 50(23):12075–12084. doi: 10.1021/ic201603v
5. Sies H, Sharov VS, Klotz LO, Briviba K (1997) Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. J Biol Chem 272(44):27812–27817
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