HIF-stabilizing biomaterials: from hypoxia-mimicking to hypoxia-inducing

Author:

Colombani Thibault1,Bhatt Khushbu2,Epel Boris34,Kotecha Mrignayani4,Bencherif Sidi A.1567ORCID

Affiliation:

1. Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA

2. Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA

3. Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA

4. Oxygen Measurement Core, O2M Technologies, LLC, Chicago, IL 60612, USA

5. Department of Bioengineering, Northeastern University, Boston, MA 02115, USA

6. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

7. Biomechanics and Bioengineering (BMBI), UTC CNRS UMR 7338, University of Technology of Compiègne, Sorbonne University, 60203 Compiègne, France

Abstract

Breakthroughs in biomaterials science have paved the way for significant advancements in the stabilization of hypoxia-inducible factor-α (HIF-α). This approach holds exciting prospects for the therapeutic use of cellular responses to low oxygen.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Chemistry (miscellaneous)

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