Detecting differential protein abundance by combining peptide level P-values
Author:
Affiliation:
1. Biological Sciences Division
2. Pacific Northwest National Laboratory
3. Richland
4. USA
5. The Gene and Linda Voiland School of Chemical Engineering and Bioengineering
Abstract
Application of empirical Brown's method to peptide intensities from comparative LC-MS proteomics experiments accurately detects differentially abundant proteins.
Funder
National Institute of Environmental Health Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Genetics,Molecular Biology,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/MO/D0MO00045K
Reference23 articles.
1. Protein Analysis by Shotgun/Bottom-up Proteomics
2. Thousand and one ways to quantify and compare protein abundances in label-free bottom-up proteomics
3. DAnTE: a statistical tool for quantitative analysis of -omics data
4. Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
5. Peptide-level Robust Ridge Regression Improves Estimation, Sensitivity, and Specificity in Data-dependent Quantitative Label-free Shotgun Proteomics
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