Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?
Author:
Affiliation:
1. School of Chemistry
2. University of Nottingham
3. University Park
4. Nottingham
5. UK
6. Division of Plant and Crop Sciences
7. School of Biosciences
8. Loughborough
Abstract
We report the first synthesis of taxadiene-4(5)-epoxide, which rearranges upon acid treatment to produce products of relevance to taxol biosynthesis.
Funder
Engineering and Physical Sciences Research Council
University Of Nottingham
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03463A
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