Oxetane Ring Formation in Taxol Biosynthesis Is Catalyzed by a Bifunctional Cytochrome P450 Enzyme-Reference-Cited by-同舟云学术

Oxetane Ring Formation in Taxol Biosynthesis Is Catalyzed by a Bifunctional Cytochrome P450 Enzyme

Published:2023-12-21 Issue:1 Volume:146 Page:801-810
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhao Yong¹^ORCID,Liang Feiyan¹,Xie Yuman¹^ORCID,Duan Yao-Tao¹,Andeadelli Aggeliki²³,Pateraki Irini¹,Makris Antonios M.²,Pomorski Thomas G.⁴^ORCID,Staerk Dan⁵^ORCID,Kampranis Sotirios C.¹^ORCID

Affiliation:

1. Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environment Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C 1871, Denmark

2. Institute of Applied Biosciences, Centre for Research & Technology, Hellas (CERTH), Thessaloniki 57001, Greece

3. Department of Food Science and Nutrition, University of the Aegean, Myrina 81100, Lemnos, Greece

4. Transport Section, Department of Plant and Environment Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C 1871, Denmark

5. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark

Funder

Danmarks Frie Forskningsfond

Novo Nordisk Fonden

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c10864

Reference58 articles.

1. Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development

2. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia