Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster

Author:

Ouyang Xiaodan1ORCID,D'Agostino Paul M.2ORCID,Wahlsten Matti1ORCID,Delbaje Endrews3ORCID,Jokela Jouni1ORCID,Permi Perttu45ORCID,Gaiani Greta1ORCID,Poso Antti6ORCID,Bartos Piia6ORCID,Gulder Tobias A. M.2ORCID,Koistinen Hannu7ORCID,Fewer David P.1ORCID

Affiliation:

1. Department of Microbiology, University of Helsinki, Viikinkaari 9, FI-00014 Helsinki, Finland

2. Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany

3. Center for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, Piracicaba 13400-970, São Paulo, Brazil

4. Department of Chemistry, University of Jyväskylä, Finland

5. Department of Biological and Environmental Science, Nanoscience Center, University of Jyväskylä, Finland

6. Kuopio Campus, School of Pharmacy, University of Eastern Finland, Finland

7. Department of Clinical Chemistry and Haematology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki FIN-00014, Finland

Abstract

Radiosumins are a structurally diverse family of low molecular weight natural products that are produced by cyanobacteria and exhibit potent serine protease inhibition.

Funder

Sigrid Juséliuksen Säätiö

Magnus Ehrnroothin Säätiö

Academy of Finland

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Hans-Fischer-Gesellschaft

Jane ja Aatos Erkon Säätiö

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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