Targeting eukaryotic proteases for natural products-based drug development-Reference-Cited by-同舟云学术

Targeting eukaryotic proteases for natural products-based drug development

Published:2020 Issue:6 Volume:37 Page:827-860
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Al-Awadhi Fatma H.¹²³⁴⁵^ORCID,Luesch Hendrik⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Faculty of Pharmacy

3. Kuwait University

4. Safat 13110

5. Kuwait

6. Department of Medicinal Chemistry

7. Center for Natural Products, Drug Discovery and Development (CNPD3)

8. University of Florida

9. Gainesville

10. USA

Abstract

This review describes the role of natural products as starting points for the development of selective protease inhibitors, examples of approved agents, the clinical and preclinical pipeline, and emerging opportunities beyond classical applications.

Funder

National Cancer Institute

Kuwait University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NP/C9NP00060G

Reference202 articles.

1. Proteases as therapeutics

2. Proteases: Multifunctional Enzymes in Life and Disease

3. Targeting proteases: successes, failures and future prospects

4. Emerging principles in protease-based drug discovery

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