Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids
Author:
Affiliation:
1. Chemistry Research Laboratory
2. Oxford
3. UK
4. Oxford Glycobiology Institute
5. University of Oxford
6. Department of Hospital Pharmacy
7. University of Toyama
8. Toyama 930-0194
9. Japan
Abstract
β-N-Acetylhexosaminidase inhibition of pipecolic, proline and azetidine amides in a cellular setting has potential as an anti-invasive anti-cancer strategy.
Funder
Leverhulme Trust
Cancer Research UK
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01549B
Reference71 articles.
1. Glycan Evolution in Response to Collaboration, Conflict, and Constraint
2. Gangliosides and Gangliosidoses: Principles of Molecular and Metabolic Pathogenesis
3. Schindler disease: An inherited neuroaxonal dystrophy due to α-N-acetylgalactosaminidase deficiency
4. Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease
5. Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients
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