Concise total synthesis of (+)-asperazine A and (+)-pestalazine B

Author:

Nelson Brandon M.1234,Loach Richard P.1234,Schiesser Stefan1234,Movassaghi Mohammad1234ORCID

Affiliation:

1. Massachusetts Institute of Technology

2. Department of Chemistry

3. Cambridge

4. USA

Abstract

The highly convergent total synthesis of dimeric diketopiperazine alkaloids (+)-asperazine A and (+)-pestalazine B is described.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference59 articles.

1. U. Anthoni , C.Christophersen and P. H.Nielsen , Naturally Occurring Cyclotryptophans and Cyclotryptamines , in Alkaloids: Chemical and Biological Perspectives , ed. S. W. Pelletier , Pergamon , London , 1999 , vol. 13 , pp. 163–236

2. T. Hino and M.Nakagawa , Chemistry and Reactions of Cyclic Tautomers of Tryptamines and Tryptophans , in The Alkaloids: Chemistry and Pharmacology , ed. A. Brossi , Academic , New York , 1989 , vol. 34 , pp. 1–75

3. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

4. Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids

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