Development of a route to chiral epidithiodioxopiperazine moieties and application to the asymmetric synthesis of (+)-hyalodendrin-Reference-Cited by-同舟云学术

Development of a route to chiral epidithiodioxopiperazine moieties and application to the asymmetric synthesis of (+)-hyalodendrin

Published:2014 Issue:5 Volume:5 Page:2003-2006
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Takeuchi Ren¹²³,Shimokawa Jun¹²³,Fukuyama Tohru¹²³

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Nagoya University

3. Aichi 464-8601, Japan

Abstract

Development of a novel methodology that takes advantage of the bridgehead carbanion and the traceless transfer of the stereochemistry of l-cysteine allowed the first asymmetric synthesis of hyalodendrin.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C3SC53222D

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1. The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

2. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

3. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

4. Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

5. Gliotoxin Is a Dual Inhibitor of Farnesyltransferase and Geranylgeranyltransferase I with Antitumor Activity Against Breast Cancer In Vivo

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