A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs-Reference-Cited by-同舟云学术

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

Published:2015 Issue:1 Volume:15 Page:301-310
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Kim Choong¹²³⁴⁵,Kasuya Junichi¹²³⁴,Jeon Jessie¹²³⁴,Chung Seok⁶⁷⁸⁹,Kamm Roger D.¹²³⁴¹

Affiliation:

1. Departments of Biological Engineering and Mechanical Engineering

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. School of Mechanical and Automotive Engineering

6. School of Mechanical Engineering

7. Korea University

8. Seoul 136-701

9. South Korea

Abstract

Anti-angiogenic therapy is now widely accepted as a treatment for cancer. We introduce a new microfluidic platform that can monitor and quantify cellular behaviors, such as morphological changes, endothelial cell viability, and formation of angiogenic sprouts, depending on the various concentrations of drug applied (i.e., bortezomib, a selective 26S proteasome inhibitor).

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2015/LC/C4LC00866A

Reference40 articles.

1. Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy

2. 3-D Tumor Model for In Vitro Evaluation of Anticancer Drugs

3. Cytotoxic Effects of 27 Anticancer Drugs in HeLa and MDR1-Overexpressing Derivative Cell Lines.

Cited by 119 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing;ACS Applied Materials & Interfaces;2024-08-28

2. An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models;Advanced Therapeutics;2024-04-26

3. Matrix Resistance Toward Proteolytic Cleavage Controls Contractility‐Dependent Migration Modes During Angiogenic Sprouting;Advanced Science;2024-03-13

4. Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries;Biofabrication;2024-03-07

5. Cancer Metastasis‐on‐a‐Chip for Modeling Metastatic Cascade and Drug Screening;Advanced Healthcare Materials;2024-01-26