A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases

Author:

Banerjee Ushashi1ORCID,Rao Pragati2,Reddy Megha3,Hussain Meeran1,Chunchanur Sneha4,Ambica R.4,Singh Amit5,Chandra Nagasuma16ORCID

Affiliation:

1. Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India

2. Department of Respiratory Medicine, M.S. Ramaiah Medical College Hospital, Bangalore, India

3. Department of General Medicine, M.S. Ramaiah Medical College Hospital, Bangalore, India

4. Bangalore Medical College and Research Institute (BMCRI), Bangalore, India

5. Center for Infectious Disease Research, Indian Institute of Science, Bangalore, India

6. Center for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India

Abstract

Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to limited specificity of the gold-standard culture sensitivity test. This study presents a host gene signature to diagnose bacterial coinfection with high confidence.

Funder

Department of Biotechnology, Ministry of Science and Technology

Indian Institute of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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