Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation-Reference-Cited by-同舟云学术

Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation

Published:2021 Issue:40 Volume:12 Page:13450-13457
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Houska Richard¹,Stutz Marvin Björn¹,Seitz Oliver¹^ORCID

Affiliation:

1. Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany

Abstract

The templated native chemical ligation between benzoyl thioesters and o-mercaptoaniline fragments proceeds in water and provides benzanilides that have nanomolar affinity for Abl1 kinase.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00513H

Reference69 articles.

1. Synthesis of Proteins by Native Chemical Ligation

2. Synthesis of Native Proteins by Chemical Ligation

3. Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

4. Native chemical ligation in protein synthesis and semi-synthesis

5. Chemical Synthesis of Proteins that cannot be Obtained Recombinantly

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