Chiral Au(<scp>iii</scp>) chelates exhibit unique NCI-60 cytotoxicity profiles and interactions with human serum albumin-Reference-Cited by-同舟云学术

Chiral Au(iii) chelates exhibit unique NCI-60 cytotoxicity profiles and interactions with human serum albumin

Published:2024 Issue:11 Volume:53 Page:5089-5104
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sookai Sheldon¹^ORCID,Akerman Matthew P.²^ORCID,Munro Orde Q.¹³^ORCID

Affiliation:

1. Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO WITS 2050, Johannesburg, South Africa

2. School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, 3201, South Africa

3. School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

Abstract

The cytotoxicity profiles of two Au(iii) chelate enantiomers were established in NCI-60 screens. Together with their differential binding to HSA, the 1S,2S enantiomer exhibits a more active molecular biology profile than the 1R,2R enantiomer.

Funder

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT04024K

Reference109 articles.

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