Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments

Author:

Frei Angelo12,Elliott Alysha G.1ORCID,Kan Alex3,Dinh Hue4,Bräse Stefan56,Bruce Alice E.7ORCID,Bruce Mitchell R.7ORCID,Chen Feng8,Humaidy Dhirgam7,Jung Nicole96ORCID,King A. Paden10,Lye Peter G.11,Maliszewska Hanna K.12,Mansour Ahmed M.13ORCID,Matiadis Dimitris14ORCID,Muñoz María Paz12,Pai Tsung-Yu3,Pokhrel Shyam7,Sadler Peter J.8ORCID,Sagnou Marina14ORCID,Taylor Michelle11,Wilson Justin J.10ORCID,Woods Dean11,Zuegg Johannes1ORCID,Meyer Wieland3,Cain Amy K.4,Cooper Matthew A.1ORCID,Blaskovich Mark A. T.1ORCID

Affiliation:

1. Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland4072, Australia

2. Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012Bern, Switzerland

3. Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, Sydney Institute for Infectious Diseases, Westmead Hospital-Research and Education Network, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW2145, Australia

4. School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW2109, Australia

5. Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131Karlsruhe, Germany

6. Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, 76344Eggenstein-Leopoldshafen, Germany

7. Department of Chemistry, University of Maine, Orono, Maine04469, United States

8. Department of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, U.K.

9. Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344Eggenstein-Leopoldshafen, Germany

10. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York14853, United States

11. School of Science and Technology, University of New England, Armidale, NSW2351, Australia

12. School of Chemistry, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, U.K.

13. Chemistry Department, Faculty of Science, Cairo University, Giza12613, Egypt

14. Institute of Biosciences & Applications, National Centre for Scientific Research “Demokritos”, 15310Athens, Greece

Funder

University of Maine

Engineering and Physical Sciences Research Council

State Scholarships Foundation

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Deutsche Forschungsgemeinschaft

University of East Anglia

Australian Research Council

Australian Government

China Scholarship Council

European Social Fund

Helmholtz Association

Anglo American

Publisher

American Chemical Society (ACS)

Subject

General Medicine

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