New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors-Reference-Cited by-同舟云学术

New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors

Published:2019 Issue:6 Volume:10 Page:1007-1017
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zidar Nace¹²³⁴^ORCID,Macut Helena¹²³⁴^ORCID,Tomašič Tihomir¹²³⁴^ORCID,Peterlin Mašič Lucija¹²³⁴,Ilaš Janez¹²³⁴^ORCID,Zega Anamarija¹²³⁴^ORCID,Tammela Päivi⁵⁶²⁷⁸^ORCID,Kikelj Danijel¹²³⁴^ORCID

Affiliation:

1. University of Ljubljana

2. Faculty of Pharmacy

3. 1000 Ljubljana

4. Slovenia

5. Drug Research Program

6. Division of Pharmaceutical Biosciences

7. University of Helsinki

8. Helsinki FI-00014

Abstract

A new series of N-phenyl-4,5-dibromopyrrolamides was developed as inhibitors of bacterial DNA gyrase B with IC₅₀ in the low nanomolar range.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Suomen Akatemia

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00224C

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