Cascade enzymatic synthesis of l-homoserine – mathematical modelling as a tool for process optimisation and design-Reference-Cited by-同舟云学术

Cascade enzymatic synthesis of l-homoserine – mathematical modelling as a tool for process optimisation and design

Published:2020 Issue:4 Volume:5 Page:747-759
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Česnik M.¹²³⁴,Sudar M.¹²³⁴^ORCID,Hernández K.⁵⁶⁷⁸⁹,Charnock S.¹⁰¹¹,Vasić-Rački Đ.¹²³⁴,Clapés P.⁵⁶⁷⁸⁹^ORCID,Findrik Blažević Z.¹²³⁴^ORCID

Affiliation:

1. University of Zagreb

2. Faculty of Chemical Engineering and Technology

3. HR-10000 Zagreb

4. Croatia

5. Institute of Advanced Chemistry of Catalonia

6. Biological Chemistry Department

7. Biotransformation and Bioactive Molecules Group

8. 08034 Barcelona

9. Spain

10. Prozomix Ltd.

11. UK

Abstract

Mathematical modelling enabled cascade reaction optimisation; 100% increase in product concentration and 18% increase in volume productivity compared to previous work.

Funder

Consejo Superior de Investigaciones Científicas

European Commission

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/C9RE00453J

Reference32 articles.

1. Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

2. Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

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