Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis-Reference-Cited by-同舟云学术

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis

Published:2021 Issue:12 Volume:12 Page:2045-2052
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Dubois Maryne A. J.¹,Croft Rosemary A.¹,Ding Yujie¹,Choi Chulho²,Owen Dafydd R.³,Bull James A.¹^ORCID,Mousseau James J.²

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London, Wood Lane, London W12 0BZ, UK

2. Medicine Design, Pfizer Worldwide Research, Development and Medical, 445 Eastern Point Rd., Groton, CT 06340, USA

3. Pfizer Medicine Design, 610 Main St, Cambridge, MA 02139, USA

Abstract

Physical property and metabolic stability comparisons are presented for designed series of drug-like compounds, containing diaryloxetanes, ketones and alkyl linkers.

Funder

Imperial College London

Pfizer

Royal Society

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00248A

Reference43 articles.

1. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

2. Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

3. Saturated bioisosteres of benzene: where to go next?

4. The importance of synthetic chemistry in the pharmaceutical industry

5. Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry

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