Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety-Reference-Cited by-同舟云学术

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

Published:2022 Issue:25 Volume:12 Page:15728-15739
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ohta Kaito¹,Fushimi Tetsuya²,Okamura Mutsumi³,Akatsuka Akinobu³,Dan Shingo³,Iwasaki Hiroki¹,Yamashita Masayuki¹,Kojima Naoto¹^ORCID

Affiliation:

1. Kyoto Pharmaceutical University, 1 Misasagi-Shichono-cho, Yamashina-ku, Kyoto 607-8412, Japan

2. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

3. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-1 Ariake-ku, Tokyo 135-8550, Japan

Abstract

The in vivo active 1-methylpyrazole-5-sulfonamide analog of acetogenins was obtained by the structure–antitumor activity relationship, focusing on the connecting groups between the heterocycle and the linker.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Kyoto Pharmaceutical University

Nippon Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA02399G

Reference50 articles.

1. Cancer Today , https://gco.iarc.fr/today , (accessed january 2022)

2. Active mitochondrial respiration in cancer: a target for the drug

3. Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment

4. Solasia Pharma K. K. , https://solasia.co.jp/en/pipeline/sp02.html , (accessed January 2022)

5. Syntheses of C2′-Fluorinated Analogs of Solamin

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