Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK-Reference-Cited by-同舟云学术

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Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Published:2023-04-28 Issue:9 Volume:66 Page:6403-6413
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ohta Kaito¹,Ii Hiromi²,Moyama Chiami²,Ando Shota²,Nambu Hisanori¹,Nakata Susumu²,Kojima Naoto¹^ORCID

Affiliation:

1. Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University, 1 Misasagi-Shichono-cho, Yamashina-ku, Kyoto 607-8412, Japan

2. Department of Clinical Oncology, Kyoto Pharmaceutical University, 5 Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Kyoto Pharmaceutical University

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00474

Reference40 articles.

1. Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis

2. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

3. Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

4. Molecular Mechanisms of Treatment Resistance in Glioblastoma

5. Human Glioma Cells Acquire Temozolomide Resistance After Repeated Drug Exposure Via DNA Mismatch Repair Dysfunction

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