Design and synthesis of new bis(1,2,4-triazolo[3,4-<i>b</i>][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition-Reference-Cited by-同舟云学术

Design and synthesis of new bis(1,2,4-triazolo[3,4-b][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition

Published:2022 Issue:36 Volume:12 Page:23644-23660
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Thabet Fatma M.¹,Dawood Kamal M.¹^ORCID,Ragab Eman A.¹,Nafie Mohamed S.²^ORCID,Abbas Ashraf A.¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

2. Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt

Abstract

A series of bis(triazolothiadiazines) and bis(quinoxalines) were synthesized and tested for their cytotoxicity and apoptosis-induction through PARP-1 and EGFR as molecular targets. Compound 8i exhibited high cytotoxic activity and promising dual enzyme inhibition.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03549A

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