Synthesis of novel piperazine-based bis(thiazole)(1,3,4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis-Reference-Cited by-同舟云学术

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Synthesis of novel piperazine-based bis(thiazole)(1,3,4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis

Published:2024 Issue:34 Volume:14 Page:24992-25006
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mohamed Doaa M.¹,Kheder Nabila A.¹,Sharaky Marwa²,Nafie Mohamed S.³⁴^ORCID,Dawood Kamal M.¹^ORCID,Abbas Ashraf A.¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

2. Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt

3. Department of Chemistry, College of Sciences, University of Sharjah, P. O. 27272, Sharjah, United Arab Emirates

4. Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt

Abstract

Compound 9i as a novel piperazine-based bis(thiazoles) and bis(thiadiazole) derivative was synthesized and characterized as potent EGFR inhibitor with promising cytotoxicity against HCT-116 cells through apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA05091F

Reference77 articles.

1. Recent Advances in Piperazine Synthesis

2. Study on synthesis, characterization and biological activity of some new nitrogen heterocycle porphyrins

3. Chloroalkyl piperazine and nitrogen mustard porphyrins: synthesis and anticancer activity

4. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

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